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J Neurol Sci. Jan 21;(1) Clinical diagnosis in Karwinskia humboldtiana polyneuropathy. Martínez HR(1), Bermudez MV, Rangel-Guerra RA. Toxicon. May;53(6) doi: /n Karwinskia humboldtiana (buckthorn) fruit causes central nervous system damage during. Karwinskia humboldtiana. Karwinskia humboldtiana (Schult.) Zucc. Coyotillo, Humboldt Coyotillo. Rhamnaceae (Buckthorn Family). Synonym(s).

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Coyotillo shrub near the Pecos River. Coyotillo, Tullidora Karwinskia humboldtiana Schult. Therefore it takes weeks for the animal to show symptoms from coyotillo foliage consumption.

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Clinical diagnosis in Karwinskia humboldtiana polyneuropathy.

This is the first report about the presence of neuronal damage caused by Kh in the Central Nervous System in chronic intoxication. It only takes 0. We designed an open trial at the Pediatric Neurology service and included all cases with acute ascending paralysis that were admitted to our hospital in the last two years.

Only humbolrtiana patient required assisted ventilation due to huumboldtiana paralysis. My concern is that the relaxation might well be permanent. This Rhamnaceae article is a stub. At any rate, this is not a fruit that anyone should ingest or even put in their mouth Bermudez et al.

Coyotillo, Tullidora

All six cases survived, with complete recovery in five. Studies have shown that the coyotillo T neurotoxin is detectable in the bloodstream of victims, which is important because the symptoms may be caused by other pathologies Martinez, et al. I do not know how lethal coyotillo is in humans, but 0. In our present work we fed the ground Kh fruit to Wistar rats and samples of brain, cerebellum, and pons were embedded in paraffin.

These occurances beg the question: Karwinskia humboldtiana Scientific classification Kingdom: The presence of Karwinskia humboldtiana toxins in blood were determined by thin layer chromatography.

The small, greenish flowers produce a green fruit that ripens to a dark purple-black color. Despite its toxic properties, parts of the coyotillo plant was used for medicinal purposes and, perhaps, even as starvation food by one group.


These cases had a symmetric motor polyneuropathy with the absence of tendon reflexes and no sensory signs or cranial nerve involvement. Small wonder so many children in Mexico are poisoned by this common and deadly shrub. Goats, sheep, and cattle are all susceptible Lyons and Machen Rhamnaceae Buckthorn Family Coyotillo is a small, evergreen shrub with deep green, almost glossy and distinctively veined leaves that grow opposite each other along the stem.

Coyotillo is a small, evergreen shrub with deep green, almost glossy and distinctively veined leaves that grow opposite each other along the stem. By using this site, you agree to the Terms of Use and Privacy Policy. We considered it important to evaluate, with histological techniques, the possible presence of lesions in the brain, by using a model of chronic intoxication that reproduces the same stages present in the human intoxication, to better understanding of this pathological process.

We present our experience in the clinical diagnosis of Karwinskia humboldtiana polyneuropathy, as confirmed by toxin detection in blood. But an experiment conducted on livestock clearly illustrates how the dangers of coyotillo fruit. It was actually eaten as starvation food in June, but over-consumption caused a serious stomach ache. Additionally, a cooked potion of the leaves was applied externally to infected wounds Martinez The poisoning manifests itself as ascending paralysis, starting in the extremities and moving toward the trunk, and in extreme cases victims need mechanical assistance to breathe.

Karwinskia humboldtianacommonly known as coyotillocacachila or Humboldt coyotillois a species of flowering shrub or small tree in the buckthorn family, Rhamnaceae. Ingestion of the fruit, especially by children, is a common source of poisoning in rural northern Mexico.

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Coyotillo is commonly found across northern Mexico in limestone soils, including the states of Nuevo Leon, Coahuila, Chihuahua, and Sonora, but it grows throughout much of Mexico. New York, New York: The literature is replete with examples of coyotillo poisoning in both livestock and humans. In six cases, T Karwinskia humboldtiana toxin was detected.

The availability of toxin detection in blood samples allows the clinician to establish an accurate diagnosis and should be included in the study of children with polyradiculoneuropathy, especially in countries where this poisonous plant grows.


Coyotillo uhmboldtiana a very poisonous plant, and stockmen know to introduce only livestock that are familiar with the vegetation of the region, or to feed plenty of humbolldtiana to those animals that aren’t. Coyotillo contains potent neurotoxins, the most prominent of which are tullidinol toxin T and peroxisomicine toxin T It is a widespread component of shrubby landscape on the southwestern edge of the Edwards Plateau, and its range extends into the south Texas Plains and across the Trans-Pecos, especially on soils derived from limestone.

Histopathological changes were evaluated in the CNS through the different stages of the polyneuropathy and comparison to a control group. Articles with ‘species’ microformats Commons category link from Wikidata Commons category link is on Wikidata All stub articles.

Children exhibiting symptoms of coyotillo poisoning, including shakes or humbpldtiana were seen by outside observers. University of Texas Press.

The Tepehuan also report using the fruit as a starvation food. However, raccoon, coyote, and fox appear to eat the berries and survive, because the scat of these animals is loaded with coyotillo seeds when the fruit is ripe. Their Environment and Material Culture. In this polyneuropathy the lesion demyelization in peripheral nerves has been described in several animal species, both in acute and in chronic intoxication.

Journal of Neurological Science 1: In conclusion, although the native poeples of the Lower Pecos Canyonlands apparently did use Coyotillo in some way, it is a highly dangerous plant.

The fruit is the most poisonous part of the Coyotillo plant, or, at least the seed inside the fruit. As an external headache remedy, the leaves were wrapped in a cloth which was in turn tied around the head. From Wikipedia, the free encyclopedia.